a defence against bacteria colonisation

Camstent is developing a surface coating that resists bacteria colonisation and inhibits biofilm development

Coating catheters should decrease CAUTI

Catheter acquired urinary tract infections (CAUTI) are the biggest cause of HAIs [1]. Solutions that can help prevent or reduce catheter-related infections will lead to significant improvements in clinical outcomes and substantial cost savings to healthcare providers.

Catheters with antibacterial coatings can be a way to reduce or retard the formation of the bacterial biofilm that leads to CAUTIs [1].

[1] Reducing HCAI- What the Commissioner needs to know. (n.d.). Retrieved November 2, 2016, from https://www.england.nhs.uk/wp-content/uploads/2015/04/10-amr-lon-reducing-hcai.pdf

But current coating technologies don't work

Coated catheters on the market, which mainly rely on silver hydrogel or antibiotics, have proven to be largely ineffective at preventing the growth of bacterial biofilm and, therefore, reducing CAUTIs [2].

Multiple clinical trials report little to no efficacy for existing products Where some positive effects were observed, they were short-lived, often lasting as little as a few hours before dissipating [1].

[2] Pickard, R., Lam, T., MacLennan, G., Starr, K., Kilonzo, M., McPherson, G., ... & Glazener, C. (2012). Antimicrobial catheters for reduction of symptomatic urinary tract infection in adults requiring short-term catheterisation in hospital: a multicentre randomised controlled trial. The lancet380(9857), 1927-1935

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Camstent's coatings being designed to resist bacteria

Camstent is working toward a a catheter coating that inhibits the formation of the bacterial biofilms are a cause of  CAUTIs.

The product can be applied to silicone/silastic surfaces.

The polymer coating resists the attachment of organisms that form toxic colonies, which should reduce the presence of bacterial toxins and may prevent patients from developing infections.

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Camstent's catheter when finalised, will offer unique and advantageous benefits over existing products:

  • Demonstrated resistance to colonisation and inhibition of biofilm development in lab experiments
  • Forms a smooth surface likely to minimize patient discomfort and acute irritation; remains bonded to the catheter throughout normal use
  • Does not kill bacteria so will not stimulate the emergence of resistant organismsEconomical, the coating is applied as a supplemental step during the catheter manufacturing process

The coating is applied as a supplemental step during manufacture, after the hollow catheter tube has been fabricated but before sterilization and packaging.